Using Stable Free Radicals to Obtain Unique and Clinically Useful Data In Vivo in Human Subjects

Abstract

This paper attempts to: (1) provide a critical overview of the challenges and opportunities to extend electron paramagnetic resonance (EPR) into practical applications in human subjects, based on EPR measurements made in vivo; (2) summarize the clinical applications of EPR for improving treatments in cancer, wound healing and diabetic care, emphasizing EPR's unique capability to measure tissue oxygen repeatedly and with particular sensitivity to hypoxia and (3) summarize the capabilities of in vivo EPR to measure radiation dose for triage and medical guidance after a large-scale radiation exposure. The conclusion is that while still at a relatively early stage of its development and availability, clinical applications of EPR already have demonstrated significant value and the field is likely to grow in both the extent of its applications and its impact on significant problems.

 

翻译

本文试图：（1）基于在体内进行的EPR测量，提供将电子顺磁共振（EPR）扩展到人类受试者的实际应用中的挑战和机会的关键概述; （2）总结了EPR在改善癌症，伤口愈合和糖尿病护理中的治疗的临床应用，强调EPR独特的测量组织氧反复和对缺氧特别敏感的能力和（3）总结体内EPR测量辐射的能力 大规模辐射照射后的分类和医疗指导剂量。 结论是，虽然EPR的临床应用仍然处于其发展和可用性的相对早期阶段，但已经显示出显着的价值，并且该领域可能在其应用程度及其对重大问题的影响方面增长。

 

说白了，EPR，很有前景，可以作为一个说法看待